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Coding agents can reproduce some functions of biological AI tools from public descriptions.
The ReproBAIT evaluation, built by the AISI with SecureBio, provides the training data and a single offline GPU.
On ProteinMPNN, Claude Opus 5 reaches 96.5% fidelity with the full paper, but RFdiffusion3 resists the tests.
According to the AISI, withholding the code of a tool therefore does not on its own guarantee safe release.